Ку10 и убихинол/CoQ10 и Ubiquinol
Absorption, Formulation and Dose:
CoQ10:
Before focusing on specific Approved products, it is important to note that research in animals suggests that only a small amount of CoQ10 is actually absorbed, although it can still significantly increase CoQ10 blood levels. CoQ10, especially the dry dosage form (tablet or capsule), is best absorbed when fats or oils are present in the gastrointestinal tract, such as during a meal. Softgels (which contain oil) may improve absorption as may the addition of oil as an ingredient. Look for products which include an oil early in the list of "Other Ingredients." Oils often used include rice bran oil, soybean oil, sunflower oil, vitamin E, and medium chain triglycerides. Products made with ingredients such as "CoQsol" and "Q-Sorb" are also in oil. For ease of reference, products with oil are noted as being "in oil" in the last column of the table below.
Even greater absorption may be achieved with CoQ10 that has been solubilized with polysorbate 80 (such as "Q-Gel") or formulated as water-soluble beadlets (sold as "All-Q"). Bioavailability tests in people with softgels containing Q-Gel, for example, showed that it achieved CoQ10 blood levels more than twice that of softgels containing CoQ10 in oil, capsules containing CoQ10 powder, or tablets made with CoQ10 powder. Another human bioavailability test showed All-Q to be nearly equal to Q-Gel and both to be superior to Q-Sorb (which is not a solubilized formula but does include rice bran oil). Another water-soluble form of CoQ10 is a cyclodextrin complex (sold as "Chew-Q" and "Hydro-Q-Sorb") which has been associated with increased absorption in laboratory models.Water-soluble formulas do not have to be taken with fats or oils. However, it is still best to take them with food because food slows down the transit time through the small intestine, which is where CoQ10 and ubiquinol (and all vitamins and minerals) are absorbed. Longer time in the intestine creates more opportunity for absorption. Water-soluble formulas of CoQ10 and ubiquinol should, obviously, also be taken with water.
Ubiquinol:
CoQ10 found in most supplements is in the oxidized state (ubiquinone), but once in the body it readily goes into the reduced state (ubiquinol), which is its active, anti-oxidant form. Ubiquinol predominates in the body. You can purchase supplements in which CoQ10 is already in the active ubiquinol state. Ubiquinol is sometimes referred to as CoQH-10 or CoQH2-10 and is marketed by a major supplier, Kaneka, as "QH." Research is not clear that it provides an advantage, although a small study of congestive heart failure patients suggested better absorption with ubiquinol than CoQ10. Ubiquinol is also sold by one company in solubilized and stabilized forms as "Li-Q-Nol," "Quinogel," "Q-Nol" and "Carni-Q-Nol" (a formula that includes L-carnitine). Like CoQ10, ubiquinol products may have better absorption if they are "solubilized." The last column of the table below indicates which ubiquinol products contain solubility enhancers.
CoQ10
Ubiquinol
* Product identical in formulation and manufacture to a product that has passed testing but sold under a different brand.
1 Not tested but claimed on label.
2 Price increased to $64.21 on October 1, 2014.
3 Price increased to $71.36 on October 1, 2014.
4 Based on price listed on puritanspride.com. Product listed on site as "Buy 1 Get 1 Free" for $18.84. 5 Based on price listed on vitaminworld.com.
